Alireza Edraki

Evolutionary Biology

University of Massachusetts Medical School

My name is Ali and I study natural inhibitors of CRISPR-Cas9. Cas9 genome editing has revolutionized medicine, but we need an off-switch for it to have better control over its action. Thankfully, nature has already designed that for us. I study proteins from phages that can inhibit Cas9 and my research aims to use these proteins to turn Cas9 off in human cells whenever we desire.

A new study shows that some are 'immune' to CRISPR. What does it mean for biology's breakthrough editor?

It's complicated, and the road from lab to clinic is long

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