Yewande Pearse

Neuroscience

LA Biomed

Born and bred in North London, I am now a Research Fellow based at LA Biomed, in affiliation with the University of California, Los Angeles (UCLA). I completed my PhD in Neuroscience at the Institute of Psychiatry in 2016, which focused on the potential use of gene therapy for the treatment of Batten disease, a fatal neurological paediatric disease. I am now working on stem cell gene therapy using CRISPR-Cas9 to treat Sanfilippo Syndrome. Before completing my PhD, I worked in the areas of Stroke and Huntington's disease research and have also worked in a care capacity, with people living with Autism, suicidal ideation, dementia and HIV Associated Neurocognitive Disorder.

Yewande has contributed to 1 report

Massive Science Report β„– 2

Opening Our Minds

Join five scientists as they explain the research behind new psychedelic treatments for mental illnesses

Yewande has authored 8 articles

Why scientists are transplanting artificially grown β€œbrains” into living brains

Scientists are making major strides in growing fully functional "mini brains" -- but what are the ethics of such science?

Comment 1 peer comment

Are hallucinations a disease?

They may be a symptom, but they are not necessarily harmful

Meet Barbara McClintock, who used corn to decipher 'jumping genes'

Through meticulous crossbreeding, she showed that DNA is far more complicated than scientists originally thought

Can exercise counteract the effects of aging on our muscles?

New research is making it seem increasingly likely – to a point

Meet Jocelyn Bell Burnell, the astrophysicist who first noticed pulsars

Through sheer tenacity she has forged a career in a male-dominated field

A rare disease offers clues to how genes affect social behavior

Williams syndrome is helping scientists understand the roots of sociality

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One great way to study brain diseases? 'Mini-brains' grown in dishes

The more complex tissue structure offers new possibilities

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Advances in gene therapy could help cure a cruel childhood illness

Most viruses make people sick. But we're learning to use them to deliver cures to complex diseases

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Pulling all-nighters may damage your brain

New research suggests bad sleep causes a build-up of plaque associated with Alzheimer's

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Like dogs? They're genetically modified organisms (from a certain point of view)

Humanity's best friend, like crops and livestock, are the product of centuries of manipulation

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Where is the boundary between life and death?

Watch the first episode of our animated Frankenstein series, Reanimation!

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The Graduate Research Fellowship Program favors elite schools – again

The early-career grants, meant to boost diversity, end up perpetuating disparities

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πŸ’© The human microbiome

Our microbiome, the collective genomes of the microbes that live inside our digestive systems, has been linked to multiple facets of our health, from cancer to depression and everything in between. However, before you go recommending one probiotic over another, you might want to read ahead.

Large studies have revealed significant variation between the gut microbiome of both healthy individuals and those with health conditions, making it hard to identify associations between the gut microbiome and a person’s health. However, thanks to two recent studies (one in Amsterdam and one in Guangdong, China), the reasons for this variation are now clearer. The two studies showed that both ethnicity and geography are key factors in determining the gut microbiome. It gets even more complicated: most of the current knowledge about the connections between the microbiome and health come from studies of European and North American populations.

This new research highlights the importance of being careful when applying data about the gut microbiome to different groups of people: clearly, one size does not fit all. However, researchers still don’t know why differences in the gut microbiome are associated with ethnicity and geography. We’ll need to untangle the influence of genetics, cultural norms, and diet if we want to develop personalized microbiome-based treatments.

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